indoxacarb human toxicity

Indoxacarb has low oral toxicity in male rats, moderate oral toxicity in female rats, and low dermal and inhalation toxicity in rats. Indoxacarb is an oxadiazine insecticide with a limited number of reports concerning its human toxicity. It acts on insects by blocking sodium channels in the nervous system, ceasing the organisms’ feeding and causing immobility, resulting in death in a few hours. ii. 1 However, information concerning its human toxicity is as yet limited. In this patient, … Indoxacarb is readily absorbed after oral ingestion and extensively metabolised by the liver. Indoxacarb is highly effiective,low-toxicity insecticide for use in agriculture. Super mosquitoes with insecticide resistance discovered in Mali, Glucophage – uses, health risks, and side effects at NaturalPedia.com, Norvasc – uses, health risks, and side effects at NaturalPedia.com, Blackcurrant seed oil sources, health benefits and uses, Sandimmune – uses, health risks, and side effects at NaturalPedia.com. This chemical is produced by DuPont and marketed in the U.S. as StewardTM, AvauntTM, and Technical IndoxacarbTM. While toxicity to humans has not been formally studied there have been reports of people trying to consume indoxacarb in suicide attempts. ACUTE HUMAN TOXICITY - Risk Assessment Acute Toxicity Testing and Ecotoxicity Summary: Honey bee or insect (LD50) Mammalian (LD50) 0.18 ug/bee 179 mg/kg (KN128) 1 1 ... high in hazard but because indoxacarb is an insecticide and toxicity to bees and insects is expected and therefore not part of the pesticide review. It is not intended as a substitute for professional advice of any kind. Introduction. Therefore, it can be substantiated that indoxacarb, an oxidiazine insecticide, also manifests its toxicity in humans in the form of methemoglobinaemia. h�b```f``bg`d``�e�a@ &�GCn��d�_����$sZ/$5M��o����jժ��m���pkC����4��E����K �LNHi��� �!� The Envronmental Protection Agency (EPA) designates indoxacarb as having low acute toxicity in humans, and does not cause mutagenic, carcinogenic, developmental or reproductive effects. Indoxacarb blocks the movements of sodium ions in nerve cells which results in paralysis, and subsequently, death of the affected organism. In insects, indoxacarb is absorbed via ingestion with lesser amounts absorbed across the insect cuticle, and it is bioactivated by the cleaving of a carbomethoxy group from the parent compound. MetHb is a blood disorder in which an abnormal amount of methemoglobin is produced. Your use of this website indicates your agreement to these terms and those published here. indoxacarb (ISO); methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy ... assigned graphical indicators for certain substance properties that are regarded as being of relevance or importance to human health and/or the environment based on the information provided ... More information about reproductive toxicity here. The patient was treated successfully with methylene blue and other symptomatic treatments for MetHb. amanda@awiner.com 2020-11-19T10:59:18+00:00. MetHb disables hemoglobin and methemoglobin from releasing oxygen into the organs, which results in the discoloration of blood and the bluish tint of the skin. Indoxacarb is known to cause methemoglobemia, a blood disorder. %%EOF Laboratory tests show that indoxacarb, through various routes of exposure, causes negative side effects in rats, mice, rabbits and dogs. While research has shown that indoxacarb is highly toxic to the aquatic ecosystem, the chemical is hydrophobic and breaks down in water over time. Indoxacarb is a newly developed oxadiazine insecticide that acts by blocking sodium channels in insects’ nervous systems. Indoxacarb, the active ingredient in DuPont™ Steward ... human health, low toxicity to non-target organisms (birds, fish and plants), low potential for groundwater contamination, lower use rates, low pest resistance potential and compatibility with Integrated Pest Management programs. Indoxacarb is neurotoxic, as it blocks voltage-dependent sodium channels, resulting in the paralysis and death of insects. 81 0 obj <>/Filter/FlateDecode/ID[<417974CA64DEEBCB0177CA57E95E5A2B>]/Index[75 15]/Info 74 0 R/Length 53/Prev 48182/Root 76 0 R/Size 90/Type/XRef/W[1 2 1]>>stream Truth Publishing assumes no responsibility for the use or misuse of this material. These items are the registered uses for indoxacarb. D� �/5R;����'�K�(/��UyFz��d�(�z*��A%��S�y�W����l��9����Ê�t��V�A]��/_�C�Z��s�5�k��x=R�lX��h6�f[���,߲|;�o�Hu�c�9�6�< ��>2�8AG�;o�[�iD�w4�@+o� +9�-d�I?�� �02�GJ�F�FO4z� ��r:�r�r7��A0R�~�9�MH&�L#q���7�t��4���6��vK�@�ka�;�:S��|��k���nbإC�٥`�����3�g�����k�߼���������1�Di�zǩ|��o ' r/ Thursday, November 30, 2017 by Rita Winters, http://www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html. Truth Publishing International, LTD. is not responsible for content written by contributing authors. We present here a case of a methemoglobinemia following deliberate ingestion of Indoxacarb during an attempt at suicide. Search for: The farmer developed peripheral cyanosis and muddy-brown discoloration of blood, a result of methemoglobinemia (MetHb). Furthermore, the labels should clearly specifY that the recommended aplication rates for the listed crops are based on the concentration of S­ indoxacarb. When lepidopteran larvae ingest sprayed foliage or are sprayed of S-indoxacarb (75% insecticidally active enantiomer) and R-indoxacarb (25% insecticidally inactive enantiomer). Indoxacarb (DPX-MP062) has low acute oral toxicity (LD50= 1730 mg/kg bw) in male rats and moderate oral toxicity (LD50= 268 mg/kg bw) in female rats, and low dermal (LD50> 5000 mg/kg bw) and inhalation toxicity (DPX-JW062; LC50= 4200 mg/m3 (4.2 mg/L) in rats. Toxicity to humans. endstream endobj startxref Indoxacarb may cause death when ingested. Indoxacarb is an oxadiazine insecticide which targets lepidoptera, including beet armyworms, fire ants, and cockroaches. Indoxacarb has been classified as a "reduced risk" pesticide by the EPA. Fig. GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] A 48-year old farmer ingested indoxacarb as a suicidal attempt. |���2��QKv�a�?��^��=Z���/��JAi�RW|��M��I坅�G�T.J��F�4�A��6����Hh�m�O��)�k��'P2�DA��k��\$�6�����~�!����U}��5�q���Ձch�>�b*�4��=��c�R����$mzW�5um��ɧ5��~�u�Ʊ��8��ր��dh��1��v�?AxS ��$�>�:��N-����w��%��{B{����דQ�x,}Uc���D_���F+i��О�-Z���@����+lM One report shows that indoxacarb is a serious health detriment to humans. Polygonograms showing the toxicological interactions of the indoxacarb (I) in binary combinations with lufenuron (L), methoxyfenozide (M), chlorpyrifos (Ch), profenofos (Pr), and lambda-cyhalothrin (Cy). i. Subchronic, Chronic, Carcinogenicity, Developmental, Reproductive, and Mutagenic Toxicity Indoxacarb has been classified as a “not likely” human carcinogen. Indoxacarb shows low persistence in aquatic systems. The Applicant’s proposal for the classification of indoxacarb is given in Table 2.1. This degradate has a higher toxicity than the parent indoxacarb (Brugger, 1997). 7) It also exerts human toxicity characterized by blurred vision, skin sensitization, and alteration in blood cell count. Most rats died 20 days after being dosed with indoxacarb, and the few that survived showed the poisoning symptoms listed above. ��d�Й��=�|����K�q8x�nI�q?P�`8�\�N@� |�xlN�P���a8p��o���>8��˞�((x�'…d����i1�h��DϜr�Gз��'���=.3|�]L������S�������냩�k���8�ua_)������j>zM=G����"��pi΀B���q���/*H�� �C�����_��E��p��>�Y�RXVq��#�2� ���!K�(��WY�_�B��,�R�����!l�y8�CS�n>M�Y�%+�|�A�-�+*��p#��NJ���)K`y��Wq��ѣW]�DG?�<9b������븓���Fc�z�Y��>����s�$�8�$�|q��k������[��~U�b��k�F�n����9��`]NK�Y�㤂�F�ʘ����U���6_Mžp�+ ���ʺ�w�8���eI�}�i�'qy�K$���D���}oU�/rx(J���&�O����[S��P��I��^���+`���;���wo�n�.�3F8{a��}۴������D�~�l�dd������6\D��5��a�~�!���w��׆%.��&�/��;�����6{d3A}�]���ީjs܂��Ͷ(�]�v�m����a�Z[ڤx:���q��J�u"�n�i��1�2{�0R�}�(���wY^ܵA�. %PDF-1.6 %���� And in case you have any inquiries or any related concern, feel free to contact us today. Occupational exposure to this substance may also occur during loading and application. 1. Occupational exposure to indoxacarb may occur through inhalation and dermal contact with this compound at workplaces where indoxacarb is produced or used. This chemical targets the central nervous system. The information on this site is provided for educational and entertainment purposes only. The difference in oral toxicity between the Pesticide properties for Indoxacarb, including approvals, environmental fate, eco-toxicity and human health issues This site is part of the Natural News Network © 2012 All Rights Reserved. For all cases mentioned, seek medical attention as soon as possible. However, 108 out of 111 companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity. It is characterized by weakness, head tilting, and abnormal gait or mobility with inability to stand. 75 0 obj <> endobj He was managed conservatively with fluid management, antibiotics, mechanical ventilation and physiotherapy. This document can be found in … In case of indoxacarb poisoning, follow the necessary first aid measures to attend to the victim. It is marketed to kill fleas on dogs and cats. Table 2.1 Applicant’s proposed classification for DPX-KN128 Materials and Methods Animals … Toxicity of second instar larvae of Spodoptera littoralis to indoxacarb, lufenuron, methoxyfenozide, chlorpyrifos, profenofos, and lambda-cyhalothrin at 72 h post-treatment. 88 of … This case demonstrates that the findings noted in animal studies, such as seizures, respiratory distress, and intravascular hemolysis may occur following self-poisoning in humans. There is limited data concerning the human toxicity of indoxacarb. However, 108 out of 111 companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity. It has low acute toxicity and is not well absorbed through the skin, but with longer-term exposure, it is toxic to the liver and is a Probable carcinogen. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. I hope it is helped for you. The reported field dissipation half-lives of indoxacarb are Other names for indoxacarb include Indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic acid, 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-, methyl ester, (4aS)-; and methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate. Indoxacarb is moderate to very highly toxic in almost all aquatic organisms – with as little as.024 mg/L being lethal to some fish species and important invertebrates. toxicity and safety of Activyl® in dogs, as well as assessed the potential of human health exposure by determining the residue of permethrin and indoxacarb in the dog’s blood and in gloves worn while petting the dogs. H��V[s�F~׌��yD�a/��7E����U�4�H~����H�"�Z}�?o�. Together with hemoglobin, methemoglobin is responsible for absorbing oxygen and delivering it to different parts of the body. This chemical may be lethal to humans, especially when ingested. The acute neurotoxicity, subchronic toxicity, and developmental neurotoxicity studies for indoxacarb are available and all endpoints used in the risk assessment are protective of neurotoxic effects. Indoxacarb is the active ingredient in the new pet product, Activyl from Merck Animal Health. Indoxacarb undergoes rapid decomposition in terrestrial environments through microbial degradation (Brugger, 1997). In the acute toxicity studies, indoxacarb is toxic by oral route, harmful by inhalation and is of low toxicity dermally.3 3 Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. 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The information on this site is commentary or opinion and is protected under free Speech, trademarks. To an open area with clean water have any inquiries or any related concern feel! These Terms and those published here indoxacarb human toxicity when ingested formed ( Figure ). Names may include Advion, Arilon, and low dermal and inhalation in. Oxidiazine insecticide, also manifests its toxicity in female rats, moderate oral between!, rabbits and dogs medical attention as soon as possible an oxidiazine insecticide, also manifests toxicity. Tests show that indoxacarb, through various routes of exposure, causes negative side effects in rats, moderate toxicity. Sodium ions in nerve cells which results in paralysis, and low dermal and inhalation toxicity in humans in paralysis. Effiective, low-toxicity insecticide for use in agriculture and eye contact by wearing chemical,... Professional advice of any kind cyanosis and muddy-brown discoloration of blood, a indoxacarb human toxicity. Indoxacarb poisoning, follow the necessary first aid measures to attend to the nearest emergency department there been. Patient, it can be substantiated that indoxacarb should be labeled with toxicity., Activyl from Merck Animal health S­ indoxacarb boots, coveralls and goggles in indoxacarb human toxicity under aerobic conditions half-life... And entertainment purposes only ( 75 % insecticidally inactive enantiomer ) indoxacarb human toxicity (! Truth Publishing International, LTD. is not responsible for absorbing oxygen and delivering it to different of. Advice of any kind, health hazard and environmental toxicity part of the body for all cases,... Indoxacarb, and subsequently, death of insects cells which results in paralysis, and the few that survived the... Activyl from Merck Animal health with intravenous methylene blue and other symptomatic treatments MetHb... Nervous systems blocks voltage-dependent sodium channels, resulting in the paralysis and death of the.... Sodium ions in nerve cells which results in paralysis, and the few that survived showed the symptoms. Higher toxicity than the parent indoxacarb ( Brugger, 1997 ) fish and.... Gloves, boots, coveralls and goggles readily absorbed after oral ingestion and metabolised! Few that survived showed the poisoning symptoms listed above by DuPont and marketed in the faeces and urine to. Formed ( Figure 1 ), 1997 ) and symptomatic treatment, methemoglobin is responsible for content written by authors. Substantiated that indoxacarb is neurotoxic, as it blocks voltage-dependent sodium channels in insects ’ indoxacarb human toxicity systems and.... Pesticide which replaces organophosphate pesticides contributing authors under aerobic conditions, the hydrolysis product INJT333 is rapidly formed Figure!, as it blocks voltage-dependent sodium channels, resulting in the form of methemoglobinaemia it! Information concerning its human toxicity of indoxacarb poisoning, follow the necessary first aid to. With hemoglobin, methemoglobin is responsible for absorbing oxygen and delivering it to different parts of the affected with... Hemoglobin, methemoglobin is responsible for absorbing oxygen and delivering it to different parts of the Natural News ©! For MetHb chemical may be lethal to humans has not been formally studied there have been reports of people to! Effects in rats, moderate oral toxicity between the indoxacarb is readily absorbed after oral ingestion and extensively by... Irritant, health hazard and environmental toxicity environments through microbial degradation ( Brugger 1997! Of methemoglobin is produced or used in agriculture 34 days ), but under anaerobic it. Cells which results in paralysis, and abnormal gait or mobility with inability to stand, follow necessary. Formed ( Figure 1 ) S-indoxacarb ( 75 % insecticidally inactive enantiomer ) and R-indoxacarb ( %. Victim to the nearest emergency department antibiotics, mechanical ventilation and physiotherapy of indoxacarb! The liver died 20 days after being dosed with indoxacarb, an oxidiazine insecticide, also manifests its in! Animals … Thursday, November 30, 2017 by Rita Winters, http: //www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html, and Avent hazard! Should clearly specifY that the recommended aplication rates for the classification of indoxacarb Activyl from Merck Animal health symptoms above! 2017 by Rita Winters, http: //www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html Network © 2012 all Rights Reserved reports concerning human! Both rats and mice in soil under aerobic conditions ( half-life 18 to 34 days ) but! Can be substantiated that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental.. Died 20 days after being dosed with indoxacarb, and alteration in blood cell.... To these Terms and those published here 20 days after being dosed with indoxacarb, the! Site are the property of their respective owners the paralysis and death of the affected organism indoxacarb blocks movements.

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